Strong team with excellent capabilities and expertise to deliver small/focused and large libraries
Multi-step preparations of novel library scaffolds
Large collections of standard commercial building blocks (amines, acids, isocyanates, sulfonyl chlorides etc.)
Small, focused libraries (20 - 500 compounds) to allow for rapid SAR exploration
Large libraries (1,000 - 10,000 compounds)
High-throughput or Parallel Medicinal Chemistry, often cherry-picked, and more complex chemistry
Track record of delivering ~88,000 compounds in the library space (small/focused and large libraries)
Capacity to deliver 6,000 compounds/month
Multiple standard orbital shakers
Multiple shakers with heating/cooling capacity
Parallel inert atmosphere equipment
CEM Discovery Microwave with robot
Large shaking table for large libraries
Parallel synthesizers for small libraries (15+)
Purification using automated prep-HPLC (06) and prep-TLC
MPLCs/Combi-Flash (08)
Small/focused libraries
10 – 50mg of each compound
Purity - ≥90% (95% if desired) by HPLC/LC-MS for all compounds
1H-NMR for 5- 10% (or more, if required) of the compounds
Large libraries
10mg of each compound
Purity - ≥85% by (90% if desired) HPLC/LC-MS for all compounds
In general 1H-NMR for 5 - 10% of the compounds
Packaging/Shipment
Depending on the project needs, we could adopt the packaging in barcoded vials/ARPs (Assay Ready Plates)
Automated system in place for ARPs in 384 wells formats, if required
Shipment to client in a desired format weekly or bi-weekly basis (or at a desired frequency)